BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

publishes research communications of outstanding significance and timeliness on topics at the interface of chemistry and biology, together with invited concise review articles. The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing new and emerging advances and concepts in these fields. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. The journal continues to be a major forum for the first publication of new chemical entities prior to them entering clinical trials.The Journal welcomes papers on:the medicinal chemistry and associated biology (including target identification and validation) of established or new disease targetsthe reporting of the discovery, design or optimization of potent new compounds or biological agentsthe analysis and discussion of structure-activity relationships and pharmacological issues relevant to drug design and action using in vitro and in vivo models, including the use of computational techniques when closely linked to experimental datathe reporting of "first-in-class" new therapeutic compoundsthe chemical biology or bioorganic/bioinorganic chemistry that significantly advances knowledge of a biological mechanismmethodological advances that are chemistry-based and which significantly impact on medicine or biologythe preparation and examination of biotherapeutics for the treatment of pathophysiological disease statesthe development of materials for specific therapeutic targetingManuscripts on phytochemistry, theoretical molecular dynamics and exclusively computational papers are out of scope. All manuscripts will be rigorously peer-reviewed by independent experts following an initial assessment by the Editors. Please note that BMCL is not suitable for straightforward reports of incremental advances. Above all the presentation of a rational basis and a sound underlying hypothesis for the work is of particular importance, whatever its exact field.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS期刊中文简介

在化学与生物学的接口上发表具有突出意义和及时性的研究通讯，并邀请简明的评论文章。该杂志发表了关于药物化学、化学生物学和药物发现与设计的实验结果的报告，强调了这些领域新的和新出现的进展和概念。这本杂志的目的是促进人们更好地了解生命过程的分子水平、活生物体以及它们与化学试剂的相互作用。该杂志仍然是在新化学实体进入临床试验之前首次出版的主要论坛。该期刊欢迎发表以下论文：已建立或新的疾病靶点的药物化学和相关生物学（包括靶点识别和确认）；发现、设计或优化有效新化合物或生物制剂的报告；利用体外和体内模型分析和讨论与药物设计和作用相关的结构-活性关系和药理学问题，包括在与实验数据密切相关时使用计算技术；“一流”新型治疗化合物的报道；显著提高生物机制知识的化学生物学或生物有机/生物无机化学；以化学为基础，对医学或生物学有重大影响的方法学进展；病理生理疾病状态生物治疗的制备与检测；特定治疗靶向材料的开发。有关植物化学、理论分子动力学和专门的计算论文的手稿超出范围。所有手稿将由独立专家在编辑初步评估后进行严格的同行评审。请注意，BMCL不适合直接报告增量预付款。最重要的是，无论工作的确切领域是什么，合理的基础和合理的基本假设的提出都是特别重要的。